Drug interactions
Fesoterodine + Marijuana
Severity: Minor
Fesoterodine and Marijuana: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis has inhibitory effects on CYP3A4 in vitro, but a clinically meaningful rise in fesoterodine metabolite levels is not established. Cannabis can also cause tachycardia, dry mouth and sedation, which may overlap with antimuscarinic effects.
What this interaction means in plain words
Fesoterodine and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by cannabinoids; not well established clinically.
What to do
No dose adjustment is needed; ask patients about cannabis use and monitor for increased anticholinergic effects such as dry mouth and dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Marijuana?
MediHelp rates the interaction as minor. Fesoterodine and Marijuana have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis has inhibitory effects on CYP3A4 in vitro, but a clinically meaningful rise in fesoterodine metabolite levels is not established. Cannabis can also cause tachycardia, dry mouth and sedation, which may overlap with antimuscarinic effects.
How serious is the interaction between Fesoterodine and Marijuana?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; ask patients about cannabis use and monitor for increased anticholinergic effects such as dry mouth and dizziness.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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