Drug interactions
Fesoterodine + Meclizine
Severity: Moderate
Fesoterodine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an antihistamine with anticholinergic and sedative properties. With fesoterodine it may cause additive dry mouth, constipation, urinary retention, drowsiness and confusion.
What this interaction means in plain words
Fesoterodine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Meclizine belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects and sedation, particularly in older adults. Limit meclizine to short-term use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Meclizine
Frequently asked questions
Can I take Fesoterodine with Meclizine?
MediHelp rates the interaction as moderate. Fesoterodine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an antihistamine with anticholinergic and sedative properties. With fesoterodine it may cause additive dry mouth, constipation, urinary retention, drowsiness and confusion.
How serious is the interaction between Fesoterodine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and sedation, particularly in older adults. Limit meclizine to short-term use where possible.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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