Drug interactions
Fesoterodine + Nafcillin
Severity: Minor
Fesoterodine and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer that may lower concentrations of the active metabolite of fesoterodine, potentially reducing bladder symptom control. The effect is likely modest and limited to the duration of nafcillin therapy.
What this interaction means in plain words
Fesoterodine and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 increases metabolic clearance of the active fesoterodine metabolite.
What to do
Monitor for reduced efficacy of fesoterodine during nafcillin therapy and reassess symptoms after the course ends.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Nafcillin?
MediHelp rates the interaction as minor. Fesoterodine and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer that may lower concentrations of the active metabolite of fesoterodine, potentially reducing bladder symptom control. The effect is likely modest and limited to the duration of nafcillin therapy.
How serious is the interaction between Fesoterodine and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of fesoterodine during nafcillin therapy and reassess symptoms after the course ends.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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