Drug interactions
Fesoterodine + Oxybutynin transdermal
Severity: Moderate
Fesoterodine and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antimuscarinics used for overactive bladder, and combining them adds anticholinergic burden without a clear efficacy advantage. Dry mouth, constipation, blurred vision and urinary retention may be more frequent.
What this interaction means in plain words
Fesoterodine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid therapeutic duplication and use one antimuscarinic at a time. If combined, monitor for anticholinergic toxicity and post-void residual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Fesoterodine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antimuscarinics used for overactive bladder, and combining them adds anticholinergic burden without a clear efficacy advantage. Dry mouth, constipation, blurred vision and urinary retention may be more frequent.
How serious is the interaction between Fesoterodine and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication and use one antimuscarinic at a time. If combined, monitor for anticholinergic toxicity and post-void residual.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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