Drug interactions
Fesoterodine + Pentobarbital
Severity: Moderate
Fesoterodine and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may reduce levels of the active metabolite of fesoterodine, possibly lessening its effect. The induction is dose and duration dependent and may be less relevant with short-term pentobarbital use.
What this interaction means in plain words
Fesoterodine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction increases clearance of the active metabolite of fesoterodine.
What to do
Monitor for diminished symptom control during prolonged pentobarbital use and adjust fesoterodine dose within labeled limits if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Pentobarbital?
MediHelp rates the interaction as moderate. Fesoterodine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may reduce levels of the active metabolite of fesoterodine, possibly lessening its effect. The induction is dose and duration dependent and may be less relevant with short-term pentobarbital use.
How serious is the interaction between Fesoterodine and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished symptom control during prolonged pentobarbital use and adjust fesoterodine dose within labeled limits if needed.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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