Drug interactions
Fesoterodine + Propantheline
Severity: Moderate
Fesoterodine and Propantheline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic drugs, so combined use increases dry mouth, constipation, urinary retention, blurred vision and tachycardia. The overlap provides little additional benefit and raises the risk of toxicity.
What this interaction means in plain words
Fesoterodine and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use of two antimuscarinics where feasible; if combined, monitor for urinary retention, constipation and tachycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Propantheline?
MediHelp rates the interaction as moderate. Fesoterodine and Propantheline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic drugs, so combined use increases dry mouth, constipation, urinary retention, blurred vision and tachycardia. The overlap provides little additional benefit and raises the risk of toxicity.
How serious is the interaction between Fesoterodine and Propantheline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antimuscarinics where feasible; if combined, monitor for urinary retention, constipation and tachycardia.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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