Drug interactions
Fesoterodine + Pyridostigmine
Severity: Moderate
Fesoterodine and Pyridostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyridostigmine enhances cholinergic transmission while fesoterodine blocks muscarinic receptors, so each may blunt the other's effect. Fesoterodine may reduce the gastrointestinal and bladder effects of pyridostigmine, and may mask cholinergic adverse effects.
What this interaction means in plain words
Fesoterodine and Pyridostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Pyridostigmine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Monitor for reduced efficacy of either drug and for urinary retention. Adjust doses according to clinical response, or use an alternative if symptoms are not controlled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Pyridostigmine
Frequently asked questions
Can I take Fesoterodine with Pyridostigmine?
MediHelp rates the interaction as moderate. Fesoterodine and Pyridostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyridostigmine enhances cholinergic transmission while fesoterodine blocks muscarinic receptors, so each may blunt the other's effect. Fesoterodine may reduce the gastrointestinal and bladder effects of pyridostigmine, and may mask cholinergic adverse effects.
How serious is the interaction between Fesoterodine and Pyridostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of either drug and for urinary retention. Adjust doses according to clinical response, or use an alternative if symptoms are not controlled.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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