Drug interactions
Fesoterodine + Thiothixene
Severity: Moderate
Fesoterodine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combining them can intensify dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older adults. Reduced gastric motility may also alter absorption of the oral antipsychotic.
What this interaction means in plain words
Fesoterodine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects, with possible slowed gastrointestinal motility.
What to do
Monitor for anticholinergic toxicity such as constipation, urinary retention and cognitive changes, especially in the elderly. Consider a lower fesoterodine dose or an alternative bladder agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Thiothixene?
MediHelp rates the interaction as moderate. Fesoterodine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combining them can intensify dry mouth, constipation, urinary retention, blurred vision and confusion, particularly in older adults. Reduced gastric motility may also alter absorption of the oral antipsychotic.
How serious is the interaction between Fesoterodine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as constipation, urinary retention and cognitive changes, especially in the elderly. Consider a lower fesoterodine dose or an alternative bladder agent if symptoms occur.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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