Drug interactions
Fesoterodine + Trifluoperazine
Severity: Moderate
Fesoterodine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has anticholinergic properties, and combining it with fesoterodine can add to peripheral and central antimuscarinic effects such as dry mouth, constipation, urinary retention and confusion. Older patients are especially vulnerable.
What this interaction means in plain words
Fesoterodine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects and cognitive status. Reduce the fesoterodine dose or switch to a non-anticholinergic bladder agent if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Trifluoperazine?
MediHelp rates the interaction as moderate. Fesoterodine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has anticholinergic properties, and combining it with fesoterodine can add to peripheral and central antimuscarinic effects such as dry mouth, constipation, urinary retention and confusion. Older patients are especially vulnerable.
How serious is the interaction between Fesoterodine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cognitive status. Reduce the fesoterodine dose or switch to a non-anticholinergic bladder agent if effects are troublesome.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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