Drug interactions
Fesoterodine + Trospium chloride
Severity: Moderate
Fesoterodine and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic bladder agents, so taking them together duplicates therapy and increases the risk of dry mouth, constipation, urinary retention, blurred vision and tachycardia. There is generally no added benefit over optimizing a single agent.
What this interaction means in plain words
Fesoterodine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication with additive muscarinic receptor blockade.
What to do
Avoid combining two antimuscarinics for overactive bladder; optimize the dose of one agent or switch class, for example to a beta-3 agonist. If used together, monitor for anticholinergic toxicity and residual urine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Trospium chloride?
MediHelp rates the interaction as moderate. Fesoterodine and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic bladder agents, so taking them together duplicates therapy and increases the risk of dry mouth, constipation, urinary retention, blurred vision and tachycardia. There is generally no added benefit over optimizing a single agent.
How serious is the interaction between Fesoterodine and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antimuscarinics for overactive bladder; optimize the dose of one agent or switch class, for example to a beta-3 agonist. If used together, monitor for anticholinergic toxicity and residual urine.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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