Drug interactions
Fesoterodine + Zotepine
Severity: Moderate
Fesoterodine and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has anticholinergic activity, so combining it with fesoterodine can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Zotepine also carries seizure and QT risks that make added anticholinergic burden less desirable.
What this interaction means in plain words
Fesoterodine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects and cognitive changes, particularly in older patients. Use the lowest effective fesoterodine dose or an alternative agent if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Zotepine?
MediHelp rates the interaction as moderate. Fesoterodine and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has anticholinergic activity, so combining it with fesoterodine can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Zotepine also carries seizure and QT risks that make added anticholinergic burden less desirable.
How serious is the interaction between Fesoterodine and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and cognitive changes, particularly in older patients. Use the lowest effective fesoterodine dose or an alternative agent if symptoms develop.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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