Drug interactions
Feverfew + Garlic
Severity: Moderate
Feverfew and Garlic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic and feverfew both inhibit platelet aggregation in laboratory studies. Combined use may modestly increase bleeding risk, especially with anticoagulants or antiplatelet drugs.
What this interaction means in plain words
Feverfew and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of platelet aggregation, with feverfew parthenolide reducing platelet secretory activity and garlic compounds such as ajoene inhibiting platelet function.
What to do
Discourage combined supplement use in patients on warfarin, DOACs or antiplatelets, and stop both about 1-2 weeks before elective surgery. Monitor for bruising and bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Frequently asked questions
Can I take Feverfew with Garlic?
MediHelp rates the interaction as moderate. Feverfew and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Garlic and feverfew both inhibit platelet aggregation in laboratory studies. Combined use may modestly increase bleeding risk, especially with anticoagulants or antiplatelet drugs.
How serious is the interaction between Feverfew and Garlic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage combined supplement use in patients on warfarin, DOACs or antiplatelets, and stop both about 1-2 weeks before elective surgery. Monitor for bruising and bleeding.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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