Drug interactions
Argatroban + Garlic
Severity: Moderate
Argatroban and Garlic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements have antiplatelet activity and may add to the anticoagulant effect of argatroban. This could increase the risk of bleeding, although clinical reports are limited.
What this interaction means in plain words
Argatroban and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Garlic belongs to Gastrointestinal Tract.
Why it happens
Garlic inhibits platelet aggregation, which adds pharmacodynamically to argatroban's direct thrombin inhibition.
What to do
Advise patients to avoid concentrated garlic supplements during argatroban therapy. Monitor aPTT and watch for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Aspirin / citric acid / sodium bicarbonate + Garlic Moderate
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Garlic?
MediHelp rates the interaction as moderate. Argatroban and Garlic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Garlic supplements have antiplatelet activity and may add to the anticoagulant effect of argatroban. This could increase the risk of bleeding, although clinical reports are limited.
How serious is the interaction between Argatroban and Garlic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid concentrated garlic supplements during argatroban therapy. Monitor aPTT and watch for signs of bleeding.
What other medicines interact with Garlic?
MediHelp also lists interactions of Garlic with, for example, Saquinavir, Aceclofenac, Acemetacin. The full list is on the Garlic page.
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