Drug interactions
Feverfew + Ibuprofen
Severity: Moderate
Feverfew and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew may inhibit platelet aggregation, which could add to the antiplatelet effect of ibuprofen and raise bleeding tendency. Clinical data are limited and the effect is mostly theoretical.
What this interaction means in plain words
Feverfew and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Feverfew constituents may inhibit platelet aggregation and prostaglandin synthesis, adding to ibuprofen's platelet inhibition.
What to do
Advise patients to avoid feverfew during regular NSAID use, and monitor for bruising or bleeding if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Feverfew with Ibuprofen?
MediHelp rates the interaction as moderate. Feverfew and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew may inhibit platelet aggregation, which could add to the antiplatelet effect of ibuprofen and raise bleeding tendency. Clinical data are limited and the effect is mostly theoretical.
How serious is the interaction between Feverfew and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid feverfew during regular NSAID use, and monitor for bruising or bleeding if combined.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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