Drug interactions
Feverfew + Meclofenamic acid
Severity: Moderate
Feverfew and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has been shown to inhibit platelet aggregation in laboratory studies, and meclofenamic acid also reduces platelet function and can injure gastric mucosa. Together they may increase bleeding tendency. Clinical data are limited.
What this interaction means in plain words
Feverfew and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects from NSAID COX inhibition and feverfew inhibition of platelet aggregation.
What to do
Advise patients to avoid feverfew while taking the NSAID, or monitor for bruising and bleeding if combined. Stop feverfew before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Feverfew and Meclofenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Feverfew with Meclofenamic acid?
MediHelp rates the interaction as moderate. Feverfew and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has been shown to inhibit platelet aggregation in laboratory studies, and meclofenamic acid also reduces platelet function and can injure gastric mucosa. Together they may increase bleeding tendency. Clinical data are limited.
How serious is the interaction between Feverfew and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid feverfew while taking the NSAID, or monitor for bruising and bleeding if combined. Stop feverfew before surgery.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
