Drug interactions
Fexinidazole + Fingolimod
Severity: Major
Fexinidazole and Fingolimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and its labeling advises against combining it with other QT-prolonging drugs. Fingolimod's bradycardia and possible QT effect further increase the risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation, with fingolimod-induced bradycardia increasing arrhythmia susceptibility.
What to do
Avoid the combination where possible, for example by pausing fingolimod if fexinidazole is essential. If it is unavoidable, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fexinidazole with Fingolimod?
MediHelp rates the interaction as major. Fexinidazole and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval, and its labeling advises against combining it with other QT-prolonging drugs. Fingolimod's bradycardia and possible QT effect further increase the risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, for example by pausing fingolimod if fexinidazole is essential. If it is unavoidable, monitor ECG and correct potassium and magnesium.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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