Drug interactions
Fexinidazole + Fluticasone-salmeterol
Severity: Major
Fexinidazole and Fluticasone-salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase exposure to salmeterol and fluticasone, and both fexinidazole and salmeterol can prolong the QT interval. The combination may produce cardiac arrhythmias and increased corticosteroid effects.
What this interaction means in plain words
Fexinidazole and Fluticasone-salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition raising salmeterol and fluticasone levels, plus additive QT prolongation.
What to do
Avoid the combination during fexinidazole treatment where possible, using a bronchodilator and corticosteroid with less CYP3A4 dependence. If unavoidable, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fexinidazole with Fluticasone-salmeterol?
MediHelp rates the interaction as major. Fexinidazole and Fluticasone-salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole inhibits CYP3A4 and may increase exposure to salmeterol and fluticasone, and both fexinidazole and salmeterol can prolong the QT interval. The combination may produce cardiac arrhythmias and increased corticosteroid effects.
How serious is the interaction between Fexinidazole and Fluticasone-salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during fexinidazole treatment where possible, using a bronchodilator and corticosteroid with less CYP3A4 dependence. If unavoidable, monitor ECG and electrolytes.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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