Drug interactions
Fexinidazole + Ifosfamide
Severity: Moderate
Fexinidazole and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a prodrug activated mainly by CYP3A4 and CYP2B6, and also forms a neurotoxic chloroacetaldehyde metabolite via CYP3A4. Fexinidazole may inhibit CYP3A4, altering the balance of active and toxic metabolites and affecting efficacy and toxicity. The clinical effect has not been well characterized.
What this interaction means in plain words
Fexinidazole and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition by fexinidazole alters ifosfamide metabolism.
What to do
Avoid the combination if possible; fexinidazole is rarely needed in oncology settings. If used together, monitor for neurotoxicity, nephrotoxicity and treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Fexinidazole with Ifosfamide?
MediHelp rates the interaction as moderate. Fexinidazole and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is a prodrug activated mainly by CYP3A4 and CYP2B6, and also forms a neurotoxic chloroacetaldehyde metabolite via CYP3A4. Fexinidazole may inhibit CYP3A4, altering the balance of active and toxic metabolites and affecting efficacy and toxicity. The clinical effect has not been well characterized.
How serious is the interaction between Fexinidazole and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; fexinidazole is rarely needed in oncology settings. If used together, monitor for neurotoxicity, nephrotoxicity and treatment response.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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