Drug interactions
Fexinidazole + Lorlatinib
Severity: Moderate
Fexinidazole and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise lorlatinib levels, increasing the risk of hyperlipidemia, CNS effects and hepatotoxicity. Fexinidazole is used for a short course in trypanosomiasis, and the interaction is largely predicted.
What this interaction means in plain words
Fexinidazole and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing lorlatinib metabolism.
What to do
Avoid concurrent use if possible, for example by timing lorlatinib interruption. If combined, monitor for lorlatinib toxicity including liver tests, lipids and CNS symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Fexinidazole with Lorlatinib?
MediHelp rates the interaction as moderate. Fexinidazole and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise lorlatinib levels, increasing the risk of hyperlipidemia, CNS effects and hepatotoxicity. Fexinidazole is used for a short course in trypanosomiasis, and the interaction is largely predicted.
How serious is the interaction between Fexinidazole and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible, for example by timing lorlatinib interruption. If combined, monitor for lorlatinib toxicity including liver tests, lipids and CNS symptoms.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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