Drug interactions
Fexinidazole + Nifedipine
Severity: Moderate
Fexinidazole and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase nifedipine exposure. This can lead to hypotension, reflex tachycardia and edema.
What this interaction means in plain words
Fexinidazole and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing nifedipine clearance.
What to do
Monitor blood pressure and heart rate during the fexinidazole course, and reduce the nifedipine dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Fexinidazole with Nifedipine?
MediHelp rates the interaction as moderate. Fexinidazole and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase nifedipine exposure. This can lead to hypotension, reflex tachycardia and edema.
How serious is the interaction between Fexinidazole and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the fexinidazole course, and reduce the nifedipine dose if symptomatic hypotension develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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