Drug interactions
Fexinidazole + Pantoprazole
Severity: Minor
Fexinidazole and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP2C19, which contributes to pantoprazole metabolism, so pantoprazole exposure may rise. The clinical consequence is likely small given pantoprazole's tolerability.
What this interaction means in plain words
Fexinidazole and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2C19 inhibition by fexinidazole or its metabolites reduces pantoprazole clearance.
What to do
No routine dose change. Monitor for pantoprazole adverse effects such as headache and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Fexinidazole with Pantoprazole?
MediHelp rates the interaction as minor. Fexinidazole and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP2C19, which contributes to pantoprazole metabolism, so pantoprazole exposure may rise. The clinical consequence is likely small given pantoprazole's tolerability.
How serious is the interaction between Fexinidazole and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change. Monitor for pantoprazole adverse effects such as headache and diarrhea.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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