Drug interactions
Fexinidazole + Pirfenidone
Severity: Moderate
Fexinidazole and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP1A2, the main enzyme clearing pirfenidone. Higher pirfenidone exposure could worsen gastrointestinal effects, photosensitivity and hepatotoxicity.
What this interaction means in plain words
Fexinidazole and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP1A2 by fexinidazole decreases pirfenidone clearance.
What to do
Monitor liver function tests and pirfenidone tolerability during the short fexinidazole course. Reduce the pirfenidone dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Frequently asked questions
Can I take Fexinidazole with Pirfenidone?
MediHelp rates the interaction as moderate. Fexinidazole and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP1A2, the main enzyme clearing pirfenidone. Higher pirfenidone exposure could worsen gastrointestinal effects, photosensitivity and hepatotoxicity.
How serious is the interaction between Fexinidazole and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and pirfenidone tolerability during the short fexinidazole course. Reduce the pirfenidone dose if adverse effects develop.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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