Drug interactions
Fexinidazole + Rasagiline
Severity: Moderate
Fexinidazole and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP1A2, the main enzyme clearing rasagiline, so rasagiline levels may rise. The clinical consequence is uncertain, and the evidence is limited.
What this interaction means in plain words
Fexinidazole and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP1A2 by fexinidazole, reducing rasagiline clearance.
What to do
Consider limiting rasagiline to 0.5 mg daily during fexinidazole therapy and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fexinidazole with Rasagiline?
MediHelp rates the interaction as moderate. Fexinidazole and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP1A2, the main enzyme clearing rasagiline, so rasagiline levels may rise. The clinical consequence is uncertain, and the evidence is limited.
How serious is the interaction between Fexinidazole and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider limiting rasagiline to 0.5 mg daily during fexinidazole therapy and monitor for adverse effects.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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