Drug interactions
Fexinidazole + Ropinirole
Severity: Moderate
Fexinidazole and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP1A2, the main enzyme clearing ropinirole. Ropinirole exposure may therefore increase, with more dopaminergic adverse effects such as sedation, nausea, hypotension and sudden sleep onset.
What this interaction means in plain words
Fexinidazole and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2 by fexinidazole or its metabolites reduces ropinirole metabolism.
What to do
Monitor for increased ropinirole effects during the short fexinidazole course and reduce the ropinirole dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexinidazole and Ropinirole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Fexinidazole with Ropinirole?
MediHelp rates the interaction as moderate. Fexinidazole and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP1A2, the main enzyme clearing ropinirole. Ropinirole exposure may therefore increase, with more dopaminergic adverse effects such as sedation, nausea, hypotension and sudden sleep onset.
How serious is the interaction between Fexinidazole and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased ropinirole effects during the short fexinidazole course and reduce the ropinirole dose if adverse effects appear.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
