Drug interactions
Fexinidazole + Salmeterol
Severity: Major
Fexinidazole and Salmeterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise salmeterol exposure, and both agents can prolong the QT interval. Together this increases the risk of palpitations, tachycardia and ventricular arrhythmia.
What this interaction means in plain words
Fexinidazole and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition raising salmeterol levels, with additive QT prolongation.
What to do
Avoid the combination during fexinidazole therapy and use an alternative bronchodilator if possible. If it is unavoidable, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Fexinidazole with Salmeterol?
MediHelp rates the interaction as major. Fexinidazole and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole inhibits CYP3A4 and may raise salmeterol exposure, and both agents can prolong the QT interval. Together this increases the risk of palpitations, tachycardia and ventricular arrhythmia.
How serious is the interaction between Fexinidazole and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during fexinidazole therapy and use an alternative bronchodilator if possible. If it is unavoidable, monitor ECG and electrolytes.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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