Drug interactions
Fexinidazole + Selegiline
Severity: Moderate
Fexinidazole and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may induce CYP2B6 and lower concentrations of CYP2B6 substrates, and selegiline is partly metabolized by CYP2B6. Reduced selegiline exposure could weaken its effect. Fexinidazole is also a concern with MAO-related interactions.
What this interaction means in plain words
Fexinidazole and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2B6 by fexinidazole increases selegiline metabolism.
What to do
Monitor for loss of selegiline efficacy during the short fexinidazole course and adjust therapy if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Fexinidazole with Selegiline?
MediHelp rates the interaction as moderate. Fexinidazole and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may induce CYP2B6 and lower concentrations of CYP2B6 substrates, and selegiline is partly metabolized by CYP2B6. Reduced selegiline exposure could weaken its effect. Fexinidazole is also a concern with MAO-related interactions.
How serious is the interaction between Fexinidazole and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of selegiline efficacy during the short fexinidazole course and adjust therapy if symptoms worsen.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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