Drug interactions
Fexinidazole + Sorafenib
Severity: Major
Fexinidazole and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and sorafenib can do the same, so the combination increases the risk of torsades de pointes. Fexinidazole may also inhibit CYP3A4 and raise sorafenib exposure.
What this interaction means in plain words
Fexinidazole and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, plus possible CYP3A4 inhibition by fexinidazole.
What to do
Avoid the combination, as fexinidazole labeling advises against other QT-prolonging drugs. If unavoidable, monitor ECGs and electrolytes and watch for sorafenib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Fexinidazole with Sorafenib?
MediHelp rates the interaction as major. Fexinidazole and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and sorafenib can do the same, so the combination increases the risk of torsades de pointes. Fexinidazole may also inhibit CYP3A4 and raise sorafenib exposure.
How serious is the interaction between Fexinidazole and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as fexinidazole labeling advises against other QT-prolonging drugs. If unavoidable, monitor ECGs and electrolytes and watch for sorafenib toxicity.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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