Drug interactions
Fexinidazole + Sunitinib
Severity: Major
Fexinidazole and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and inhibits CYP3A4, so it may raise sunitinib exposure while adding to QT risk. This increases the likelihood of both sunitinib toxicity and arrhythmia.
What this interaction means in plain words
Fexinidazole and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by fexinidazole raises sunitinib levels, with additive QT prolongation.
What to do
Avoid coadministration; if sunitinib is essential, defer fexinidazole or select another treatment. If unavoidable, monitor ECG and electrolytes and consider reducing the sunitinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Fexinidazole with Sunitinib?
MediHelp rates the interaction as major. Fexinidazole and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and inhibits CYP3A4, so it may raise sunitinib exposure while adding to QT risk. This increases the likelihood of both sunitinib toxicity and arrhythmia.
How serious is the interaction between Fexinidazole and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; if sunitinib is essential, defer fexinidazole or select another treatment. If unavoidable, monitor ECG and electrolytes and consider reducing the sunitinib dose.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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