Drug interactions
Fexinidazole + Timolol
Severity: Major
Fexinidazole and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and cause bradycardia, and timolol slows heart rate. Combining them may increase the risk of significant bradyarrhythmia and, with QT effects, serious arrhythmia.
What this interaction means in plain words
Fexinidazole and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bradycardic and negative chronotropic effects, with fexinidazole QT prolongation.
What to do
Avoid the combination where possible. If it is needed, monitor ECG and heart rate and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Fexinidazole with Timolol?
MediHelp rates the interaction as major. Fexinidazole and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and cause bradycardia, and timolol slows heart rate. Combining them may increase the risk of significant bradyarrhythmia and, with QT effects, serious arrhythmia.
How serious is the interaction between Fexinidazole and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is needed, monitor ECG and heart rate and correct potassium and magnesium.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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