Drug interactions
Fexinidazole + Tolvaptan
Severity: Moderate
Fexinidazole and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise tolvaptan concentrations. This can lead to excessive aquaresis and rapid serum sodium changes.
What this interaction means in plain words
Fexinidazole and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing tolvaptan metabolism.
What to do
Monitor serum sodium and volume status and lower the tolvaptan dose if needed. Fexinidazole is given for a short course, so reassess tolvaptan dosing after it ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Fexinidazole with Tolvaptan?
MediHelp rates the interaction as moderate. Fexinidazole and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise tolvaptan concentrations. This can lead to excessive aquaresis and rapid serum sodium changes.
How serious is the interaction between Fexinidazole and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and volume status and lower the tolvaptan dose if needed. Fexinidazole is given for a short course, so reassess tolvaptan dosing after it ends.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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