Drug interactions
Filgrastim + Ifosfamide
Severity: Moderate
Filgrastim and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Filgrastim stimulates proliferation of myeloid progenitor cells, which makes them more vulnerable to cytotoxic agents such as ifosfamide. Giving it close to chemotherapy can worsen myelosuppression and blunt the intended neutrophil recovery.
What this interaction means in plain words
Filgrastim and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Filgrastim belongs to Miscellaneous; Ifosfamide belongs to Oncology.
Why it happens
Growth factor-driven cycling of rapidly dividing myeloid cells increases their sensitivity to cytotoxic chemotherapy.
What to do
Do not give filgrastim from 24 hours before until 24 hours after ifosfamide chemotherapy. Monitor neutrophil counts through the nadir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Filgrastim with Ifosfamide?
MediHelp rates the interaction as moderate. Filgrastim and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Filgrastim stimulates proliferation of myeloid progenitor cells, which makes them more vulnerable to cytotoxic agents such as ifosfamide. Giving it close to chemotherapy can worsen myelosuppression and blunt the intended neutrophil recovery.
How serious is the interaction between Filgrastim and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give filgrastim from 24 hours before until 24 hours after ifosfamide chemotherapy. Monitor neutrophil counts through the nadir.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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