Drug interactions
Fingolimod + Gemtuzumab
Severity: Moderate
Fingolimod and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin carries a QT prolongation warning, and fingolimod slows heart rate. Together they may increase arrhythmia risk. Fingolimod's immunosuppression is also a concern in patients with leukemia.
What this interaction means in plain words
Fingolimod and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation with fingolimod-induced bradycardia.
What to do
Monitor ECG and electrolytes during treatment. Review whether fingolimod continuation is appropriate during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Gemtuzumab?
MediHelp rates the interaction as moderate. Fingolimod and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin carries a QT prolongation warning, and fingolimod slows heart rate. Together they may increase arrhythmia risk. Fingolimod's immunosuppression is also a concern in patients with leukemia.
How serious is the interaction between Fingolimod and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during treatment. Review whether fingolimod continuation is appropriate during chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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