Drug interactions
Fingolimod + Hydrocortisone
Severity: Moderate
Fingolimod and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, and combined use may raise the risk of infection. Fingolimod labeling advises caution when combining it with immunosuppressants. Short courses of corticosteroids are used in practice for relapses.
What this interaction means in plain words
Fingolimod and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Hydrocortisone belongs to Endocrine.
Why it happens
Additive immunosuppression through corticosteroid effects and fingolimod-induced lymphocyte sequestration.
What to do
Monitor for signs of infection and use the lowest effective corticosteroid dose for the shortest duration. Check the lymphocyte count and consider the risk of prolonged therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Hydrocortisone?
MediHelp rates the interaction as moderate. Fingolimod and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, and combined use may raise the risk of infection. Fingolimod labeling advises caution when combining it with immunosuppressants. Short courses of corticosteroids are used in practice for relapses.
How serious is the interaction between Fingolimod and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and use the lowest effective corticosteroid dose for the shortest duration. Check the lymphocyte count and consider the risk of prolonged therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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