Drug interactions
Fingolimod + Ibritumomab tiuxetan
Severity: Major
Fingolimod and Ibritumomab tiuxetan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibritumomab tiuxetan delivers radiation and depletes B cells, causing prolonged cytopenias, and fingolimod adds lymphocyte reduction, raising infection risk.
What this interaction means in plain words
Fingolimod and Ibritumomab tiuxetan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive myelosuppression and lymphocyte reduction.
What to do
Monitor complete blood counts and signs of infection; avoid fingolimod during the period of expected cytopenias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Ibritumomab tiuxetan?
MediHelp rates the interaction as major. Fingolimod and Ibritumomab tiuxetan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibritumomab tiuxetan delivers radiation and depletes B cells, causing prolonged cytopenias, and fingolimod adds lymphocyte reduction, raising infection risk.
How serious is the interaction between Fingolimod and Ibritumomab tiuxetan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection; avoid fingolimod during the period of expected cytopenias.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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