Drug interactions
Fingolimod + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Fingolimod and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod reduces the antibody response to vaccines, including influenza vaccine. Vaccination remains possible but may give weaker protection.
What this interaction means in plain words
Fingolimod and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lymphocyte sequestration by fingolimod blunts the humoral immune response to vaccination.
What to do
Inactivated influenza vaccine can still be given, as it is not contraindicated, but do not rely on full response. Where feasible, vaccinate before starting fingolimod, and reinforce other protective measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Fingolimod and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod reduces the antibody response to vaccines, including influenza vaccine. Vaccination remains possible but may give weaker protection.
How serious is the interaction between Fingolimod and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inactivated influenza vaccine can still be given, as it is not contraindicated, but do not rely on full response. Where feasible, vaccinate before starting fingolimod, and reinforce other protective measures.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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