Drug interactions
Fingolimod + Inotuzumab
Severity: Major
Fingolimod and Inotuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin is associated with QT prolongation, and fingolimod causes bradycardia and may affect QT. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Fingolimod and Inotuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation, with fingolimod-induced bradycardia increasing arrhythmia susceptibility.
What to do
Obtain ECG and electrolytes before starting and periodically during treatment. Correct potassium and magnesium, and consider interrupting fingolimod if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Inotuzumab?
MediHelp rates the interaction as major. Fingolimod and Inotuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotuzumab ozogamicin is associated with QT prolongation, and fingolimod causes bradycardia and may affect QT. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Fingolimod and Inotuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and electrolytes before starting and periodically during treatment. Correct potassium and magnesium, and consider interrupting fingolimod if the QTc becomes markedly prolonged.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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