Drug interactions
Fingolimod + Irinotecan liposomal
Severity: Moderate
Fingolimod and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liposomal irinotecan is a myelosuppressive cytotoxic agent, and fingolimod lowers circulating lymphocytes by sequestering them in lymph nodes. Together they can deepen immune suppression and raise the risk of serious infection.
What this interaction means in plain words
Fingolimod and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic immunosuppression from chemotherapy-induced myelosuppression and fingolimod-mediated lymphocyte sequestration.
What to do
Monitor complete blood counts, especially lymphocyte and neutrophil counts, and watch for signs of infection. Consider whether fingolimod should be interrupted during myelosuppressive chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Fingolimod and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liposomal irinotecan is a myelosuppressive cytotoxic agent, and fingolimod lowers circulating lymphocytes by sequestering them in lymph nodes. Together they can deepen immune suppression and raise the risk of serious infection.
How serious is the interaction between Fingolimod and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts, especially lymphocyte and neutrophil counts, and watch for signs of infection. Consider whether fingolimod should be interrupted during myelosuppressive chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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