Drug interactions
Fingolimod + Lithium
Severity: Moderate
Fingolimod and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod can slow heart rate and prolong the QT interval, particularly after the first dose. Lithium has been linked to sinus node dysfunction and, rarely, QT changes, so the combination may add to the risk of bradycardia and arrhythmia.
What this interaction means in plain words
Fingolimod and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac conduction and repolarization.
What to do
Obtain a baseline ECG and observe heart rate and rhythm during fingolimod initiation. Correct potassium and magnesium and reassess if bradycardia or QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Lithium?
MediHelp rates the interaction as moderate. Fingolimod and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod can slow heart rate and prolong the QT interval, particularly after the first dose. Lithium has been linked to sinus node dysfunction and, rarely, QT changes, so the combination may add to the risk of bradycardia and arrhythmia.
How serious is the interaction between Fingolimod and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and observe heart rate and rhythm during fingolimod initiation. Correct potassium and magnesium and reassess if bradycardia or QT prolongation develops.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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