Drug interactions
Fingolimod + Measles vaccine
Severity: Major
Fingolimod and Measles vaccine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod suppresses lymphocyte trafficking, which may blunt the immune response to a vaccine. A live attenuated vaccine also carries a risk of uncontrolled vaccine-strain infection in an immunosuppressed patient.
What this interaction means in plain words
Fingolimod and Measles vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
S1P receptor modulation reduces circulating lymphocytes, impairing vaccine response and the ability to control live attenuated virus replication.
What to do
Avoid live vaccines during fingolimod therapy and for about two months after stopping. Give any needed live vaccine at least one month before starting fingolimod.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fingolimod and Measles vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Measles vaccine?
MediHelp rates the interaction as major. Fingolimod and Measles vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod suppresses lymphocyte trafficking, which may blunt the immune response to a vaccine. A live attenuated vaccine also carries a risk of uncontrolled vaccine-strain infection in an immunosuppressed patient.
How serious is the interaction between Fingolimod and Measles vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during fingolimod therapy and for about two months after stopping. Give any needed live vaccine at least one month before starting fingolimod.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
