Drug interactions
Fingolimod + Meningococcal group b vaccine
Severity: Moderate
Fingolimod and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod reduces lymphocyte trafficking and can blunt antibody responses to vaccines. The meningococcal B vaccine is non-live, so it is safe to give, but protection may be lower.
What this interaction means in plain words
Fingolimod and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fingolimod-induced lymphocyte sequestration reduces vaccine immune response.
What to do
Where possible, vaccinate at least 4 weeks before starting fingolimod. If already on treatment, vaccinate anyway and consider checking antibody response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Fingolimod and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod reduces lymphocyte trafficking and can blunt antibody responses to vaccines. The meningococcal B vaccine is non-live, so it is safe to give, but protection may be lower.
How serious is the interaction between Fingolimod and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate at least 4 weeks before starting fingolimod. If already on treatment, vaccinate anyway and consider checking antibody response.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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