Drug interactions
Fingolimod + Metipranolol
Severity: Moderate
Fingolimod and Metipranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod slows heart rate and conduction after the first dose, and a beta-blocker adds to this effect. Although metipranolol is given as eye drops, systemic absorption can occur and may contribute to bradycardia or AV block, especially when fingolimod is started or restarted after an interruption.
What this interaction means in plain words
Fingolimod and Metipranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative chronotropic and dromotropic effects from S1P receptor modulation on atrial myocytes and beta-adrenergic blockade.
What to do
Obtain a baseline ECG and monitor heart rate and blood pressure for at least 6 hours after the first fingolimod dose or after a treatment interruption. Consider extended monitoring if bradycardia or conduction abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Metipranolol?
MediHelp rates the interaction as moderate. Fingolimod and Metipranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod slows heart rate and conduction after the first dose, and a beta-blocker adds to this effect. Although metipranolol is given as eye drops, systemic absorption can occur and may contribute to bradycardia or AV block, especially when fingolimod is started or restarted after an interruption.
How serious is the interaction between Fingolimod and Metipranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and blood pressure for at least 6 hours after the first fingolimod dose or after a treatment interruption. Consider extended monitoring if bradycardia or conduction abnormalities develop.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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