Drug interactions
Fingolimod + Mycophenolate
Severity: Major
Fingolimod and Mycophenolate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate suppresses T- and B-lymphocyte proliferation, while fingolimod reduces circulating lymphocytes. Used together they may increase the risk of serious infections and malignancy.
What this interaction means in plain words
Fingolimod and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression via inhibition of lymphocyte proliferation and lymphocyte sequestration.
What to do
Avoid combining where an alternative exists. If used together, monitor lymphocyte counts and infection signs closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Mycophenolate?
MediHelp rates the interaction as major. Fingolimod and Mycophenolate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mycophenolate suppresses T- and B-lymphocyte proliferation, while fingolimod reduces circulating lymphocytes. Used together they may increase the risk of serious infections and malignancy.
How serious is the interaction between Fingolimod and Mycophenolate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists. If used together, monitor lymphocyte counts and infection signs closely.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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