Drug interactions
Fingolimod + Octreotide
Severity: Moderate
Fingolimod and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and fingolimod also slows heart rate and may affect QT. The combination may increase the risk of arrhythmia, particularly in patients with heart disease or electrolyte disturbances.
What this interaction means in plain words
Fingolimod and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive bradycardic and QT-prolonging effects.
What to do
Obtain a baseline ECG and monitor heart rate and ECG after fingolimod initiation; correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Fingolimod with Octreotide?
MediHelp rates the interaction as moderate. Fingolimod and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and fingolimod also slows heart rate and may affect QT. The combination may increase the risk of arrhythmia, particularly in patients with heart disease or electrolyte disturbances.
How serious is the interaction between Fingolimod and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor heart rate and ECG after fingolimod initiation; correct potassium and magnesium abnormalities.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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