Drug interactions
Fingolimod + Procainamide
Severity: Major
Fingolimod and Procainamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod produces bradycardia and conduction delay, and procainamide slows conduction and prolongs QT. Together they may increase the risk of AV block and ventricular arrhythmia.
What this interaction means in plain words
Fingolimod and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bradycardic and conduction-slowing effects with QT prolongation.
What to do
Avoid if possible; if needed, obtain cardiology advice and perform extended ECG monitoring at fingolimod initiation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Procainamide?
MediHelp rates the interaction as major. Fingolimod and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod produces bradycardia and conduction delay, and procainamide slows conduction and prolongs QT. Together they may increase the risk of AV block and ventricular arrhythmia.
How serious is the interaction between Fingolimod and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, obtain cardiology advice and perform extended ECG monitoring at fingolimod initiation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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