Drug interactions
Fingolimod + Protriptyline
Severity: Moderate
Fingolimod and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as protriptyline can prolong the QT interval and conduction, and fingolimod-related bradycardia adds to arrhythmic risk. The combination may be more hazardous in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Fingolimod and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac conduction and repolarization, with bradycardia as a risk amplifier.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor ECG during fingolimod initiation and consider an alternative antidepressant in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Protriptyline?
MediHelp rates the interaction as moderate. Fingolimod and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as protriptyline can prolong the QT interval and conduction, and fingolimod-related bradycardia adds to arrhythmic risk. The combination may be more hazardous in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Fingolimod and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor ECG during fingolimod initiation and consider an alternative antidepressant in high-risk patients.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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