Drug interactions
Fingolimod + Romidepsin
Severity: Major
Fingolimod and Romidepsin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation, and fingolimod can cause bradycardia. The combination may raise the risk of ventricular arrhythmia, particularly with low potassium or magnesium.
What this interaction means in plain words
Fingolimod and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with fingolimod-induced bradycardia increasing the risk.
What to do
Check potassium and magnesium and obtain a baseline ECG before treatment. Monitor ECG during therapy and avoid the combination in patients with significant cardiac risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Romidepsin?
MediHelp rates the interaction as major. Fingolimod and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin has been associated with ECG changes including QT prolongation, and fingolimod can cause bradycardia. The combination may raise the risk of ventricular arrhythmia, particularly with low potassium or magnesium.
How serious is the interaction between Fingolimod and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and obtain a baseline ECG before treatment. Monitor ECG during therapy and avoid the combination in patients with significant cardiac risk.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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