Drug interactions
Fingolimod + Streptozocin
Severity: Moderate
Fingolimod and Streptozocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin is a cytotoxic alkylating agent that can cause myelosuppression, and fingolimod reduces lymphocyte counts. The combination may increase infection risk.
What this interaction means in plain words
Fingolimod and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic immunosuppression from cytotoxic effects and lymphocyte sequestration.
What to do
Monitor blood counts and infection signs. Consider holding fingolimod during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Streptozocin?
MediHelp rates the interaction as moderate. Fingolimod and Streptozocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptozocin is a cytotoxic alkylating agent that can cause myelosuppression, and fingolimod reduces lymphocyte counts. The combination may increase infection risk.
How serious is the interaction between Fingolimod and Streptozocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs. Consider holding fingolimod during chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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