Drug interactions
Fingolimod + Venlafaxine
Severity: Moderate
Fingolimod and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and conduction delay on initiation and has been linked to QT prolongation. Venlafaxine may add a minor QT effect. The combination may increase arrhythmia risk, mainly around the first dose.
What this interaction means in plain words
Fingolimod and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization, with fingolimod-induced bradycardia increasing arrhythmia vulnerability.
What to do
Obtain an ECG before the first fingolimod dose and observe heart rate and blood pressure after the first dose per labeling. Extend monitoring if the patient has QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Venlafaxine?
MediHelp rates the interaction as moderate. Fingolimod and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod causes bradycardia and conduction delay on initiation and has been linked to QT prolongation. Venlafaxine may add a minor QT effect. The combination may increase arrhythmia risk, mainly around the first dose.
How serious is the interaction between Fingolimod and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before the first fingolimod dose and observe heart rate and blood pressure after the first dose per labeling. Extend monitoring if the patient has QT risk factors.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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