Drug interactions
Fingolimod + Yellow fever vaccine
Severity: Contraindicated
Fingolimod and Yellow fever vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yellow fever vaccine is a live attenuated vaccine, and fingolimod's lymphocyte sequestration impairs immune control of vaccine virus. This risks disseminated vaccine-strain infection and a poor vaccine response.
What this interaction means in plain words
Fingolimod and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Fingolimod traps lymphocytes in lymph nodes, causing immunosuppression that allows replication of the live vaccine.
What to do
Avoid live vaccines during and for about two months after stopping fingolimod. Give any needed live vaccine at least 4 weeks before starting, or arrange a medical exemption for travel.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Fingolimod and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Yellow fever vaccine is a live attenuated vaccine, and fingolimod's lymphocyte sequestration impairs immune control of vaccine virus. This risks disseminated vaccine-strain infection and a poor vaccine response.
How serious is the interaction between Fingolimod and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during and for about two months after stopping fingolimod. Give any needed live vaccine at least 4 weeks before starting, or arrange a medical exemption for travel.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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