Drug interactions
Fingolimod + Zoster vaccine recombinant
Severity: Moderate
Fingolimod and Zoster vaccine recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod reduces lymphocyte trafficking and may blunt the immune response to vaccination. The recombinant zoster vaccine is non-live, so it is safe to give, but protection may be lower.
What this interaction means in plain words
Fingolimod and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lymphocyte sequestration by fingolimod reduces the vaccine-induced humoral and cellular response.
What to do
Where possible, give the vaccine before starting fingolimod, ideally several weeks beforehand. If the patient is already on fingolimod, vaccinate anyway because the vaccine is non-live and accept a potentially reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Zoster vaccine recombinant?
MediHelp rates the interaction as moderate. Fingolimod and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod reduces lymphocyte trafficking and may blunt the immune response to vaccination. The recombinant zoster vaccine is non-live, so it is safe to give, but protection may be lower.
How serious is the interaction between Fingolimod and Zoster vaccine recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine before starting fingolimod, ideally several weeks beforehand. If the patient is already on fingolimod, vaccinate anyway because the vaccine is non-live and accept a potentially reduced response.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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